Beilstein J. Nanotechnol.2020,11, 508–532, doi:10.3762/bjnano.11.41
biopolymers. The selection of a sacrificial template for capsule formation, the driving forces involved, the encapsulation of a variety of cargo and release based on different internal and external stimuli have also been addressed. We describe recent perspectives and obstacles of weakpolyelectrolyte
/biopolymer systems in applications such as therapeutics, biosensing, bioimaging, bioreactors, vaccination, tissue engineering and gene delivery. This review gives an emerging outlook on the advantages and unique responsiveness of weakpolyelectrolyte based systems that can enable their widespread use in
PDF
Figure 1:
Schematic representation showing the capsule fabrication, drug encapsulation and release of loaded ...
Beilstein J. Nanotechnol.2015,6, 2504–2512, doi:10.3762/bjnano.6.260
the nanoparticles with high concentrations of sodium chloride shows no further release and thus demonstrates the pH-driven release to be quantitative.
Keywords: layer-by-layer self-assembly; pH-triggered release; PLGA nanoparticles; polyelectrolyte multilayers; weakpolyelectrolyte; Introduction
The
, polyelectrolyte multilayers have already in various cases been applied for pH-driven release, based on weakpolyelectrolyte components [22][23][24][25][26][27].
Nanoparticles can be used as carrier systems for the transport of drugs to cells and tissues. Once getting in contact with cells nanoparticles can be
, which could be attributed to successful adsorption of the cationic PEI layer.
pH-Sensitivity of the PAA layer in dependence on the adsorption pH value
PAA, as a weakpolyelectrolyte with a charge density depending on pH, can be easily adsorbed onto positively charged substrates, such as PLGA
PDF
Figure 1:
Sketch of terminating layer conformation for PLGA-PEI-PAA nanoparticles prepared at pH 3 in a) ultr...